In vitro pharmacology data for Aminopyridine 1 and 2
Values were determined as described in the Materials and Methods section and presented as the geometric mean of at least three independent experiments.
| Aminopyridine Compound | MPO IC50 | MPO kinact/Ki | MPO k3/k4 | MPO Dialysis | TPO IC50 | TPO Selectivity |
|---|---|---|---|---|---|---|
| µM | M−1s−1 | % recovered activity | µM | Fold | ||
| 1 | 0.45 | 14,000 | 57 | 42 | >100 | >222 |
| 2 | 0.16 | 76,500 | 11 | 8 | >100 | >588 |