TABLE 2

Summary of pharmacokinetic data for Aminopyridine 2 in preclinical species

The pharmacokinetics of Aminopyridine 2 in mice, rats, and dogs are summarized. Aminopyridine 2 concentrations were measured from plasma collected at specific time points, and pharmacokinetic parameters were calculated. All data are reported as the mean (n = 2–3).

SpeciesOral Cmax
at 10 mg/kg Oral Tmax
at 10 mg/kgOral AUC 0–∞CLpVdsst1/2Oral F
nMhnM/h per milliliterml/min per kilograml/kgh%
Mouse11,8841.358,4404.50.71.951
Rat 20,8440.4133,1624.51.34.1∼100
Dog19,4862.3335,6151.90.97∼100
  • AUC, area under the curve; CLp, plasma clearance; Oral F, oral bioavailibility; t1/2, half-life; Tmax, time to maximal concentration; Vdss, volume of distribution.