Model parameters employed in the extended mPBPK model simulations
| Parameter | Definition | Value | Unit | Reference |
|---|---|---|---|---|
| σ1 | Vascular reflection coefficient for tight tissue | 0.95 | — | Cao and Jusko (2014b) |
| σ2 | Vascular reflection coefficient for leaky tissue | 0.71 | — | Cao and Jusko (2014b) |
| σL | Lymphatic reflection coefficient | 0.20 | — | Garg and Balthasar (2007) |
| σV | Vascular reflection coefficient for target tissue | 0.50 | — | Cao and Jusko (2014a) |
| L | Total lymph flow | 2.9/24 | l·h−1 | Lindena et al. (1986) |
| L1 | Lymph flow for tight tissue | 0.0399 | l·h−1 | Shah and Betts (2012) |
| L2 | Lymph flow for leaky tissue | 0.081 | l·h−1 | Shah and Betts (2012) |
| CLp | Systemic clearance | 0.01 | l·h−1 | Cao and Jusko (2014b) |
| LT | Lymph flow for target tissue (2% of total) | 0.00242 | l·h−1 | Davies and Morris (1993) |
| Vtight | ISF for tight tissue | 8.112 | l | Cao and Jusko (2014a) |
| Vleaky | ISF for leaky tissue | 4.368 | l | Cao and Jusko (2014a) |
| VT | ISF for target tissue (2% of total ISF) | 0.314 | l | Davies and Morris (1993) |
| Vlymph | Lymph volume | 5.2 | l | Davies and Morris (1993) |
| Vp | Plasma volume | 2.6 | l | Davies and Morris (1993) |
| kdeg | Free target degradation rate | 4.2 | h−1 | Cao and Jusko (2014a) |
| ksyn | Target biosynthesis rate in target tissue | 4.2 | nM·h−1 | Cao and Jusko (2014a) |