FS315-hFc Variant | Hyperglycosylation Site | N95 | N112 | N259 | |||||
---|---|---|---|---|---|---|---|---|---|
Location | Occupancy | Sialic Contenta | Occupancy | Sialic Contenta | Occupancy | Sialic Contenta | Occupancy | Sialic Contenta | |
Wild type | 14.7% | 2.3 | 13.6% | 0.9 | 96.0% | 1.3 | |||
ΔHBS | 22.7% | 1.8 | 20.2% | 1.7 | 98.8% | 1.7 | |||
K82T | N80 | N.D. | N.D. | 49.7% | 1.7 | 16.2% | 0.8 | 97.1% | 1.2 |
P85T | N83 | N.D. | N.D. | 9.3% | 2.4 | 18.6% | 1.1 | 97.0% | 1.3 |
R78N/N80T | N78 | N.D. | N.D. | 31.3% | 2.4 | 17.7% | 1.0 | 97.0% | 1.4 |
R86N/V88T | N86 | b | b | 21.0%b | 1.0b | 15.1% | 1.0 | 96.7% | 1.1 |
G74N/K76T/P85T | N74 | N.D. | N.D. | 15.0% | 2.2 | 23.1% | 1.3 | 95.4% | 1.3 |
N83 | N.D. | N.D. | |||||||
K75N/C77T/K82T | N75 | 69.7% | 2.0 | 47.9% | 2.3 | 16.9% | 1.5 | 97.0% | 1.4 |
N80 | N.D. | N.D. | |||||||
C66A/K75N/C77T | N75 | 39.6% | 1.9 | 32.8% | 2.3 | 17.8% | 1.4 | 94.9% | 1.3 |
C66S/K75N/C77T | N75 | 21.5% | 2.0 | 32.9% | 2.4 | 19.7% | 1.4 | 95.1% | 1.3 |