Treatment and Dose | Response Rate (Number of Responses/Number of Injections) and Percentage (5%) | ||||
---|---|---|---|---|---|
Urination | Defecation | Retching and Emesis | Lacrimation | Salivation | |
μg/kg, i.v. | |||||
Vehicle | 0/40 (0) | 0/40 (0) | 0/40 (0) | 0/40 (0) | 0/40 (0) |
1 | 2/40 (5.0) | 3/40 (7.5) | 0/40 (0) | 0/40 (0) | 0/40 (0) |
10 | 39/40 (97.5)* | 33/40 (82.5)* | 1/40 (2.5) | 2/40 (5.0) | 5/40 (12.5) |
30 | 40/40 (100)* | 39/40 (97.5)* | 11/40 (27.5)* | 9/40 (22.5)* | 17/40 (42.5)* |
↵* P ≤ 0.01 compared with vehicle, Fisher’s exact test.