Incidence of urination, defecation, emesis, lacrimation, and salivation after single intravenous injection of LMN-NKA (1–100 μg/kg)
Values are the number of observations from 16 to 20 dogs per group from studies 1–4. Equal numbers of male and female dogs were examined and the data were pooled since no difference between sexes was apparent. Animals were observed continuously for 10 minutes after intravenous injection of LMN-NKA.
| Treatment and Dose | Response Rate (Number of Responders/N per Group) and Percentage (%) | ||||
|---|---|---|---|---|---|
| Urination | Defecation | Retching and Emesis | Lacrimation | Salivation | |
| μg/kg, i.v. | |||||
| Vehicle | 0/16 (0) | 0/16 (0) | 0/16 (0) | 0/16 (0) | 0/16 (0) |
| 1 | 0/16 (0) | 0/16 (0) | 0/16 (0) | 0/16 (0) | 0/16 (0) |
| 10 | 18/20 (90.0)* | 7/20 (35.0) | 2/20 (10.0) | 0/20 (0) | 0/20 (0) |
| 100 | 18/18 (100)* | 9/18 (50.0)* | 3/18 (16.7) | 1/18 (5.5) | 6/18 (33.3) |
↵* P ≤ 0.01 compared with vehicle, Fisher’s exact test.