Effects of AVP or V1b antagonists on alcohol-related behaviors
| Subjects | Sex | Model | Effect | Reference |
|---|---|---|---|---|
| Brattleboro homozygote rats | Male | 2-Bottle choice (24 h, 2%–10%) | Decrease (intake) by systemic (osmotic pump) DGAVP | Rigter and Crabbe (1985) |
| Rhesus monkeys | Male, female | Multiple-bottle choice (24 h,1%–8%) | Decrease (intake) by systemic (i.v.) DGAVP | Kornet et al. (1991) |
| Sardinian alcohol-preferring rats | Male | 2-Bottle choice (24 h, 10%) | Decrease (intake and preference) by systemic (i.p.) SSR149415 | Zhou et al. (2011) |
| Alcohol-dependent Wistar rats | Male | Operant self-administration (10%, 30 min) | Decrease (intake) by systemic (i.p.) or intracentral amygdala SSR149415 | Edwards et al. (2012) |
| C57Bl/6J mice | Male, female | 2-Bottle choice (24 h, every other day, 15%) | Decrease (intake and preference) by systemic (i.p.) SSR149415 | Zhou et al. (2018) |
| Humans | Male, female | Phase 2, double-blind, placebo-controlled, randomized trial | Decrease (intake and relapse) by systemic (oral) ABT-436 | Ryan et al. (2017) |
ABT-436, V1b antagonist; DGAVP, desglycinamide-(Arg8)-vasopressin; SSR149415, V1b antagonist.