TABLE 2

Antagonist affinity values (pKB) of prazosin, RS 100329, 5-methylurapidil, and BMY 7378 for the norepinephrine-induced contractions of proximal and distal CE segments

The slopes of linear regressions derived from Schild analysis of antagonism of norepinephrine-induced contractions in the proximal and distal CE are also shown. Data represent mean ± S.E.M. from n different segments taken from different rats.

ProximalDistal
pKBSlopepKBSlope
Prazosin9.15 ± 0.061.06 ± 0.12 (n = 5)9.51 ± 0.020.98 ± 0.03 (n = 5)
RS 1003299.31 ± 0.030.93 ± 0.07 (n = 5)9.63 ± 0.020.96 ± 0.04 (n = 5)
5-Methylurapidil8.58 ± 0.050.92 ± 0.09 (n = 6)9.03 ± 0.031.02 ± 0.05 (n = 5)
BMY 73786.57 ± 0.130.98 ± 0.32 (n = 6)6.99 ± 0.040.91 ± 0.07 (n = 5)