TABLE 2

Estimated parameters for bortezomib effects on temporal myeloma cell proliferation

Parameter (unit)Estimate % CV
U266RPMI8226MM.1SNCI-H929
kg (h−1)0.0192a0.0169a0.0214a0.0235a
Kmax (h−1)0.0710 (11)0.0671 (7.3)0.170 (30)0.244 (26)
KC50 (nM)3.49 (22)2.62 (14)5.87 (52)14.3 (53)
γ1.32 (23)1.54 (23)1.34 (23)0.966 (14)
R01.00a1.00a1.00a1.00a
σ20.372 (10)0.392 (11)0.0468 (49)0.367 (11)
  • a Fixed parameter value.