TABLE 1

Estimated pharmacodynamic parameters for bortezomib concentration-effect analysis

Time (h)Parameter (unit)Estimate % CV
U266RPMI8226MM.1SNCI-H929
24IC50 (nM)4.75 (3.8)4.71 (3.9)2.28 (1.6)3.60 (3.7)
R0 (%)98.3 (2.8)107 (3.6)93.3 (1.5)106 (3.8)
γ5.00a4.39 (12)5.00a4.48 (5.8)
Imax0.872 (1.6)0.974 (1.4)1.00a0.985 (0.14)
48IC50 (nM)3.69 (2.2)2.99 (1.8)1.77 (1.3)3.03 (1.4)
R0 (%)107 (3.2)102 (2.2)96.9 (1.9)102 (1.8)
γ5.00a5.00a5.00a5.00a
Imax0.963 (0.24)1.00a1.00a1.00a
72IC50 (nM)3.37 (2.1)2.58 (2.3)1.11 (1.4)2.47 (1.1)
R0 (%)94.1 (3.6)100 (3.7)116 (3.3)84.1 (1.5)
γ5.00a5.00a5.00a5.00a
Imax0.981 (0.13)1.00a1.00a1.00a
  • a Fixed parameter value.