Comparative antiseizure ED50 values of GX and AP in mouse models of epilepsy
Values in parentheses are 95% confidence limits.
| AP | GX | References | |
|---|---|---|---|
| mg/kg | mg/kg | ||
| Kindling models | |||
| Hippocampus kindling | 3.5 | 3.5 | Reddy et al. (2012), Carver et al. (2014) |
| Amygdala kindling | 14 (8–23) | 6.6 (5.1–9.7) | Reddy and Rogawski (2010) |
| Cocaine kindling | 17.0 (ND) | 17.0 (ND) | Kaminski et al. (2003) |
| Pentylenetetrazol kindling | ND | 3.5 (2.4–5.1) | Gasior et al. (2000) |
| Corneal kindling | ND | 4.5 (4.0–5.1) | Carter et al. (1997) |
| Chemoconvulsant models | |||
| Pentylenetetrazol (mice) | 13.7 (10.1–18.7) | 3.5 (2.1–5.8) | Kokate et al. (1994), Carter et al. (1997) |
| Pentylenetetrazol (rats) | 2.14 (1.10–4.15) | 4.3 (2.8–6.9) | Reddy and Rogawski (2000, 2001) |
| Bicuculline | 12 (10–15) | 4.6 (3.2–6.8) | Carter et al. (1997) |
| Picrotoxin | 10 (5–19) | ND | Belelli et al. (1989) |
| t-Butylbicycloorthobenzoate | ND | 11.7 (8.8–15.7) | Carter et al. (1997) |
| Flurothyl (rats) | ND | 5.0 (ND) | Liptakova et al. (2000) |
| N-Methyl-d-aspartate | >40 | >30 | Carter et al. (1997) |
| Kainic acid | >40 | >30 | Carter et al. (1997) |
| 4-Aminopyridine | >40 | 11.5 (8.1–16.3) | Carter et al. (1997) |
| Strychnine | >40 | >40 | Carter et al. (1997) |
| Electroshock models | |||
| Maximal electroshock | 29 (19–44) | 29.7 (25.3–34.8) | Carter et al. (1997) |
| 6-Hz stimulation | 4.2 (2.7–5.8) | 1.5 (1.3–1.7) | Carver and Reddy (2016) |
| Status epilepticus models | |||
| Pilocarpine | 7 (4–11) | ∼6 | Kokate et al. (1996), Briyal and Reddy (2008) |
| Kainic acid | ∼20 | ND | Rogawski et al. (2013) |
ND, not determined.