TABLE 3

Pharmacokinetic parameters of mirogabalin and pregabalin in STZ-induced diabetic rats

Mirogabalin besylate and pregabalin were orally administered (2 ml/kg). Dose levels and concentrations of test compounds are expressed as free form. Each value represents the mean ± S.E.M. (N = 3).

DrugDose Day 1Day 5
CmaxAUC0–12 hoursCmaxAUC0–12 hours
mg/kgμg/mlμg⋅h/mlμg/mlμg⋅h/ml
Mirogabalin2.50.5 ± 0.12.6 ± 0.50.5 ± 0.11.9 ± 0.0
51.5 ± 0.07.2 ± 0.81.0 ± 0.15.2 ± 0.7
103.2 ± 0.010.9 ± 0.52.5 ± 0.215.1 ± 2.7
Pregabalin107.0 ± 1.942.4 ± 0.46.8 ± 0.546.3 ± 6.4
2011.6 ± 3.369.4 ± 7.014.9 ± 0.794.2 ± 17.6
4020.3 ± 0.5148.7 ± 13.726.7 ± 2.7165.3 ± 16.7