TABLE 2

Dissociation kinetic parameters of 3H-mirogabalin and 3H-pregabalin for the α2δ subunits

The 95% confidence limits are in parentheses.

SubtypeParameterMirogabalinPregabalin
Human α2δ-1Koff [h−1]0.0627 (0.0423–0.0831)0.5051 (0.4817–0.5286)
t1/2 [h]11.1 (8.3–16.4)1.4 (1.3–1.4)
Human α2δ-2Koff [h−1]0.2837 (0.2441–0.3233)0.5103 (0.2603–0.7603)
t1/2 [h]2.4 (2.1–2.8)1.4 (0.9–2.7)
Rat α2δ-1Koff [h−1]0.0798 (0.0629–0.0966)0.4929 (0.4297–0.5561)
t1/2 [h]8.7 (7.2–11.0)1.4 (1.2–1.6)
Rat α2δ-2Koff [h−1]0.3027 (0.2359–0.3695)0.5266 (0.3937–0.6595)
t1/2 [h]2.3 (1.9–2.9)1.3 (1.1–1.8)
  • t1/2, dissociation half-life.