TABLE 4

CNS side effects profile of mirogabalin and pregabalin in rats

Dose levels of test compounds are expressed as free form. Safety index was obtained by calculating the ratio between side effect ED50 (rota-rod ED50 or locomotor ED50) and analgesic ED50 (on day 1 in STZ diabetic model).

MirogabalinPregabalin
Analgesic ED50STZ diabetic model4.4 mg/kg26.8 mg/kg
CNS side-effect ED50Rota-rod performance9.4 mg/kg11.7 mg/kg
Locomotor activity43.9 mg/kg111.8 mg/kg
Safety indexRota-rod performance2.10.4
Locomotor activity10.04.2