Drug Constants | Symbol | Value | Reference |
---|---|---|---|
Molecular weight | Mol. wt. | 335.872 | |
Lipophilicity | Log10 (Kow) | 3.84 | Warhurst et al. (2003) |
First dissociation constant | pKa1 | 9.67 | |
Second dissociation constant | pKa2 | 8.27 | |
Lysosomal parameters | |||
Lysosomal lipid fraction | L | 0.05 | Trapp et al. (2008) |
Lysosomal water fraction | W | 0.95 | Trapp et al. (2008) |
Neutral activity coefficient | γN | 1.23 | Trapp et al. (2008) |
First activity coefficient | γ1 | 0.74 | Trapp et al. (2008) |
Second activity coefficient | γ2 | 0.3 | Trapp et al. (2008) |
Lysosomal radius | rlys (μm) | 0.275 | Kawashima et al. (1998) |
Lysosomal buffering capacity | β (mM) | 46 | Ishizaki et al. (2000) |
Lysosomal pH | pHlys | 5.0 | Trapp et al. (2008) |
Cytosolic pH | pHcyt | 7.2 | Trapp et al. (2008) |
Lysosome contenta | |||
Kidney | % Tissue volume | 0.05 | |
Heart | 0.1 | ||
Eye | 0.015 | ||
Skin | 0.1 | ||
Gut | 0.1 | ||
Liver | 0.05 | ||
Slowly perfused | 0.1 | ||
Rapidly perfused | 0.2 |
↵a Starting values from Sewell et al. (1986) and Kawashima et al. (1998). Final values determined from acid phosphatase and optimization.