TABLE 3

Measure of predictive performance of the PBPK model for mouse (tissues) and human (blood and urine) data

DoseTissue/PatientMAPE%MPE%
20 mg/kgBlood27.25−11.06
Liver73.25−41.16
Kidney33.89−25.28
Gut39.35−31.87
40 mg/kgBlood23.93−23.93
Liver71.31−46.90
Kidney27.488.17
Gut18.528.08
80 mg/kgBlood37.01−37.01
Liver43.80−24.80
Kidney24.195.90
Gut23.529.90
200 mg (oral)4 (blood)18.6414.79
5 (urine)15.53−3.34
200 mg (i.v.)4 (blood)33.51−11.58
5 (urine)20.999.55
1 (blood)42.1317.36
400 mg (i.v.)1 (blood)39.3220.82