TABLE 1

AUC for plasma ATV and RTV

Data are expressed as average (ng d/ml) ± S.E.M. Significantly different from NOG mice value: *P < 0.05; ****P < 0.0001. Significantly different from 50 mg/kg nanoATV/r treated mice of similar strain: P < 0.05; ††P < 0.001.

Strain and TreatmentNATVRTV
ng d/mlng d/ml
hCYP3A-NOG mice, 20 mg/kg nanoATV/r
 All84891 ± 663*868 ± 229
 Male54498 ± 686663 ± 77
 Female35548 ± 7301209 ± 306
hCYP3A-NOG mice, 50 mg/kg nanoATV/r
 All719,430 ± 2058****3687 ± 439
 Male416,729 ± 13093023 ± 463
 Female323,031 ± 2110a4457 ± 584
hCYP3A-NOG mice, 50 mg/kg nanoATV
 All57111 ± 717††
NOG mice, 20 mg/kg nanoATV/r
 All82621 ± 7811674 ± 863
 Male52201 ± 2341778 ± 1088
 Female33322 ± 12371498 ± 453
NOG mice, 50 mg/kg nanoATV/r
 All74590 ± 5162087 ± 217
 Male44101 ± 1982056 ± 339
 Female35242 ± 6542130 ± 300
NOG mice, 50 mg/kg nanoATV
 All52402 ± 486
  • a Significantly different from nanoATV/r male mice of similar strain and treatment (P < 0.05).