TABLE 1 

List of signature drug metabolizing enzyme and transporter genes included in panel

Phase IPhase IIUptake TransportersEfflux TransportersNRs + Non-DME Targets
AOX1GSTA1SLC10A1/NTCPABCB1/MDR1AhR
CES1GSTP1SLC22A1/OCT1ABCB4/MDR3NR0B2/SHP
CYP1A1SULT1E1SLC22A7/OAT2ABCB11/BSEPNR1H4/FXR
CYP2B6UGT1A1SLC47A1/MATE1ABCC2/MRP2NR1I2/PXR
CYP2C8UGT1A4SLCO1B1/OATP1B1ABCC3/MRP3NR1I3/CAR
CYP2C9UGT1A6SLCO1B3/OATP1B3ABCC4/MRP4PDK4
CYP2C19UGT1A9SLCO2B1/OATP2B1ABCC5/MRP5PPARα
CYP2D6UGT2B4ABCC6/MRP6
CYP3A4UGT2B7ABCG2/BCRP
EPHX1UGT2B15
EPHX2
HSD11β1
  • AOX, aldehyde oxidase; BSEP, bile salt export salt; CES1, carboxylesterase 1; FXR, farnesoid X receptor; OCT1 organic cation transporter 1; PDK4, pyruvate dehydrogenase kinase 4; SHP, small heterodimer partner (also known as NR0B2).