TABLE 1

Morphine ED₅₀ values in milligrams per kilogram (95% confidence limits) to reverse paclitaxel-induced mechanical hypersensitivity before and after repeated treatment with either saline or 3.2 mg/kg per day morphine on days 23–28

Treatment and Test Day	Males	Females
Repeated saline
Day 22	1.9 (1.4–2.8)	1.8 (1.3–2.7)
Day 29	2.2 (1.6–3.0)	1.9 (1.4–2.6)
Repeated morphine
Day 22	1.6 (1.1–2.3)	1.5 (1.2–1.9)
Day 29	3.7 (2.6–5.4)^a	2.6 (2.1–3.1)^a

↵^a Statistically significant difference from day 22 as indicated by nonoverlapping confidence limits.