TABLE 4 

Percentage changes from baseline in cardiovascular parameters 5 min after intravenous exposure of anesthetized pigs to prucalopride or solvent (water)

Data are median percentage changes from control values. Changes from baseline of <10% vs. control were considered physiologically irrelevant

Percentage change in parameterConcentration of prucalopride or solvent (mg/kg per minute)
Low-dose rangeaHigh-dose rangeb
0.020.040.080.160.160.320.631.25
PRUSOLPRUSOLPRUSOLPRUSOLPRUSOLPRUSOLPRUSOLPRUSOL
HR9−53−89−422−819−214−47−36−6
AoPd7−1115550218017−417−411−8
AoPs3061−33−208−17−39−33−6
LVEDP−6−3−5−3−152−195−13−15−1−10−7−62
LVdp/dtmax2−7−4−19−4−22−6−324−8−5−20−12−30−22−33
LVdp/dtmin6−46−71−75−119−211−34−39−12
SV−13−5−23−11−26−16−33−14−40−16−11−15−12−22−17
CO6−8−4−175−209−19122−3−19−9−12−17−17
PRP13−54−85−114−1029−432−223−112−6
Relaxation (τ)−11−311−2157140−23−38−65−3
SVR361321425−17225115618017−1
PVR−15194229342928−9010129242323
PQ interval00307−1−3101214−150
QRS duration−1−1000−23−10−5−1−1−12−10
QT interval−6−1−8−4−10−3−11−5−3−1−5−3−5−9−6−8
QTcB interval−1−2−6−7−3−6−4−84−10−5−3−7−4−8
QTcF interval−2−2−7−6−4−6−6−81−1−2−2−4−5−5−5
QTcV interval−4−1−6−5−4−5−6−7−2−1−3−1−4−55−5
  • AoPd, diastolic aortic blood pressure; AoPs, systolic aortic blood pressure; CO, cardiac output; HR, heart rate; PRP, platelet-rich plasma; PRU, prucalopride; PVR, pulmonary vascular resistance; QTcB, Bazett-corrected QT interval; QTcF, Fridericia-corrected QT interval; QTcV, Van de Water-corrected QT interval; SOL, solvent (control); SV, stroke volume; SVR, systemic vascular resistance.

  • a Maximum plasma concentrations ranged from 6.7 ng/ml (0.02 mg/kg) to 79.8 ng/ml (0.16 mg/kg).

  • b Maximum plasma concentrations ranged from 70 ng/ml (0.16 mg/kg) to 757 ng/ml (1.25 mg/kg).