Effect of prucalopride on cardiovascular parameters in anesthetized rabbits (n = 7) during methoxamine administration
Values are mean ± S.E.M. All prucalopride concentrations tested resulted in plasma concentrations that exceeded therapeutic concentrations in man.
| Parameter | Water (ml/kg per minute for 60 minutes) | Prucalopride (mg/kg per minute for 60 minutes) | |||
|---|---|---|---|---|---|
| 0.125 | 0.04 | 0.08 | 0.16 | 0.31 | |
| HR (beats/min) | 188 ± 9 | 215 ± 13 | 181 ± 8 | 166 ± 12 | 179 ± 11 |
| MAP (mmHg) | 63 ± 8 | 70 ± 7 | 60 ± 3 | 49 ± 3 | 47 ± 5 |
| PR-interval (ms) | 90 ± 4 | 90 ± 3 | 92 ± 2 | 106 ± 5* | 97 ± 3 |
| QRS duration (ms) | 32 ± 1 | 32 ± 2 | 36 ± 2 | 39 ± 2* | 39 ± 2* |
| Amplitude of P wave (mV) | 0.13 ± 0.01 | 0.13 ± 0.01 | 0.1 ± 0.01 | 0.09 ± 0.02 | 0.10 ± 0.01 |
| Amplitude of R wave (mV) | 0.62 ± 0.06 | 0.52 ± 0.07 | 0.62 ± 0.09 | 0.56 ± 0.05 | 0.61 ± 0.08 |
| QT interval (ms) | 198 ± 10 | 180 ± 12 | 218 ± 8 | 294 ± 25* | 291 ± 22* |
| JT interval (ms) | 166 ± 9 | 147 ± 11 | 181 ± 8 | 255 ± 24* | 251 ± 21* |
| QTc interval (ms) | 348 ± 12 | 336 ± 14 | 377 ± 10 | 481 ± 26* | 493 ± 23* |
| JTc interval (ms) | 291 ± 12 | 274 ± 14 | 313 ± 11 | 416 ± 26* | 426 ± 23* |
| QT dispersion (ms) | 10 ± 4 | 14 ± 4 | 12 ± 3 | 11 ± 1 | 15 ± 2 |
| QTc dispersion (ms) | 18 ± 6 | 26 ± 7 | 20 ± 2 | 17 ± 2 | 25 ± 3 |
HR, heart rate; MAP, mean arterial pressure.
↵* P < 0.05 vs. solvent (water).