TABLE 1 

Electrophysiological effects of prucalopride in isolated guinea pig papillary muscle

Stimulations were performed under normal rhythm conditions (1 Hz) and normokalemia (KCl 4 mM). Values are mean ± S.E.

ParameterVehicle (n = 6)Prucalopride (µM; n = 8)
BaselineFirstSecondThirdFourthBaseline0.010.1110
AAP (mV)127 ± 2124 ± 3126 ± 2129 ± 2131 ± 2127 ± 2126 ± 3127 ± 2128 ± 2126 ± 3
APD90 (ms)176 ± 5181 ± 5a183 ± 6a180 ± 6181 ± 6a176 ± 6177 ± 6178 ± 8188 ± 7a201 ± 6a
APD50 (ms)152 ± 5158 ± 5a160 ± 5a157 ± 6157 ± 6a154 ± 5154 ± 6156 ± 7165 ± 6a174 ± 5a
RMP (mV)92 ± 289 ± 291 ± 190 ± 190 ± 290 ± 188 ± 288 ± 290 ± 188 ± 2
Vmax (V/s)200 ± 4189 ± 6206 ± 8193 ± 9211 ± 16218 ± 14216 ± 7b218 ± 9219 ± 11221 ± 6
CF (MN)1.54 ± 0.391.56 ± 0.401.52 ± 0.401.47 ± 0.401.40 ± 0.41a1.41 ± 0.221.43 ± 0.221.37 ± 0.261.46 ± 0.241.34 ± 0.23
  • AAP, amplitude of resting action potential; APD90, action potential duration at 90% repolarization; APD50, action potential duration at 50% repolarization; CF, contractile force; RMP, resting membrane potential; Vmax, maximum rate of depolarization during the upstroke.

  • a P ≤ 0.05 vs. own baseline value.

  • b P ≤ 0.05 vs. vehicle.