TABLE 1

Treatment schedules in vivo

Group No.Treatment groupTreatment descriptionGroup category
22Rv1 xenograft mice
 (1)ControlControlControl
 (2)Doc 5Doc 5 mg/kg per weekMonotherapy
 (3)Doc 10Doc 10 mg/kg per weekMonotherapy
 (4)Cab 10Cab 10 mg/kg per dayMonotherapy
 (5)Doc 5 + Cab 10Doc 5 mg/kg per week and Cab 10 mg/kg per day, simultaneous administrationConcurrent schedule
 (6)Doc 10 + Cab 10Doc 10 mg/kg per week and Cab 10 mg/kg per day, simultaneous administrationConcurrent schedule
 (7)Doc 5 6h Cab 10Doc 5 mg/kg per week and Cab 10 mg/kg per day, with 6-hour intervalInterval schedule
 (8)Doc 10 6h Cab 10Doc 10 mg/kg per week and Cab 10 mg/kg per day, with 6-hour intervalInterval schedule
 (9)Doc 10 ∼ Cab 10Doc 10 mg/kg per week for the first week, followed by Cab 10 mg/kg per day for the second week, and alternated weeklySequential schedule
PC3 xenograft mice
 (1)ControlControlControl
 (2)Doc 5Doc 5 mg/kg per weekMonotherapy
 (3)Cab 10Cab 10 mg/kg per dayMonotherapy
 (4)Doc 5 + Cab 10Doc 5 mg/kg per week and Cab 10 mg/kg per day, simultaneous administrationConcurrent schedule
 (5)Doc 5 6h Cab 10Doc 5 mg/kg per week and Cab 10 mg/kg per day, with 6-hour intervalInterval schedule
 (6)Doc 5 − Cab 10Doc 5 mg/kg per week for the first week, followed by Cab 10 mg/kg per day for the second week, and alternated weeklySequential schedule
 (7)Cab 10 ∼ Doc 5Cab 10 mg/kg per day for the first week, followed by Doc 5 mg/kg per week for the second week, and alternated weeklySequential schedule
  • All drug administration was conducted at 8:00 AM except the interval groups. For mice on a concurrent schedule, Doc and Cab were administered simultaneously (8:00 AM) on the first day of every week. For mice on an interval schedule, Cab was administered 6 hours after the Doc injection (i.e., Doc was injected at 8:00 AM and Cab was given by gavage at 2:00 PM).