TABLE 1

Sorafenib and dasatinib concentrations in plasma and tumors 4 hours after the last dose

Data are presented as mean ± S.D.

Dasatinib (40 mg/kg daily)Sorafenib (40 mg/kg daily)Dasatinib (20 mg/kgdaily) + Sorafenib (20 mg/kg daily)
n = 8n = 7n = 8
C4h,plasma (μM)
 Dasatinib1.16 ± 0.320.67 ± 0.48
 Sorafenib13.85 ± 4.045.38 ± 2.53
C4h,A549 xenograft (μM)
 Dasatinib2.70 ± 1.351.74 ± 0.59
 Sorafenib7.74 ± 2.834.15 ± 1.36
C4h,A549 xenograft: C4h,plasma ratio
 Dasatinib2.32 ± 4.273.18 ± 1.54
 Sorafenib0.57 ± 0.200.84 ± 0.33
C4h,A549/SRFres xenograft (μM)
 Dasatinib3.34 ± 1.741.82 ± 0.68
 Sorafenib9.39 ± 4.393.24 ± 1.89
C4h,A549/SRFres xenograft: C4h,plasma ratio
 Dasatinib2.87 ± 5.513.24 ± 1.59
 Sorafenib0.69 ± 0.330.61 ± 0.32