Displacement of [3H]Ro 25-6981 binding to native GluN2B receptors in membranes prepared from rat forebrain, cynomolgus monkey frontal cortex, or human frontal cortex
| Compound | Rat (Mean Ki ± S.D.) | Monkey (Mean Ki ± S.D.) | Human (Mean Ki ± S.D.) |
|---|---|---|---|
| nM | nM | nM | |
| BMS-986169 | 4.03 ± 1.39 (n = 13) | 4.2 ± 0.8 (n = 3) | 6.3 ± 1.5 (n = 3) |
| CP-101,606 | 6.96 ± 0.56 (n = 3) | 2.2 ± 0.5 (n = 4) | 3.1 ± 0.9 (n = 4) |
| MK-0657 | 2.52 ± 0.42 (n = 3) | 3.2 ± 0.5 (n = 3) | 4.4 ± 1.4 (n = 3) |