TABLE 3

Mean oral pharmacokinetic parameters of GSK1278863 in the rat

Values are expressed as mean and S.D. of parameter, where appropriate (n = 3); serial sampling design in male Sprague-Dawley rats.

Dose	C_max	T_max^{^a}	AUC_0–24h	AUC_0–∞	DNAUC_0–24h
mg/kg	μg/ml	h	μg.h/ml	μg.h/ml	μg.h/ml/mg/kg
1.6^{^b}	2.86 ± 0.51	4.0	46.61 ± 8.95	106.63 ± 19.97	29.13
31.1^{^c}^,^{^d}	62.40 ± 3.78	2.0	941.02 ± 68.91	ND	30.26

AUC_0–24h, area under the plasma concentration-time curve within 0 to 24 hours; AUC_0–∞, area under the plasma concentration-time curve from time 0 to infinity; DNAUC0-24h, dose-normalized area under the plasma concentration-time curve within 0 to 24 hours; ND, not determined since % extrapolated AUC_0–∞ was high.
↵^a T_max expressed as median.
↵^b Solution in 2% DMSO, 20% (w/v) Captisol in water, pH∼7.0.
↵^c Suspension in 1% methylcellulose.
↵^d Animals were not fasted overnight before dosing.