TABLE 2 

Summary of the pharmacokinetics of GSK1278863

Values are expressed as mean and S.D. of parameter, where appropriate (n = 3).

SpeciesCLbVdssT1/2MRTOral F (%)
ml/min/kgl/kghh
Mousea0.70.3ND7.888
Rat0.2 ± 0.020.4 ± 0.133.5 ± 6.236.7 ± 4.7∼100b
Dog0.9 ± 0.20.5 ± 0.16.6 ± 2.18.8 ± 2.746 ± 6
Monkey8.4 ± 0.20.8 ± 0.11.9 ± 0.11.6 ± 0.134 ± 8
  • CL, clearance; MRT, mean residence time; ND, not determined; Vdss, steady-state volume of distribution.

  • a Composite sampling design (n = 3 animals per time point).

  • b Noncrossover design, data estimated from mean i.v. data.