TABLE 3 

Effect of selected compounds on A431 cells, Jurkat cells, and human PBMCs

CompoundEC50
EGF-Induced EGFR Phosphorylation in A431 CellsaAnti-CD3/CD28–Induced IL-2 Production in Jurkat CellsbAnti-CD3–Induced CD25 Expression in PBMCsb
nM
1>10,000>10,000>10,000
271 ± 1499 ± 17257 ± 71
34680 ± 720150 ± 22575 ± 60
7327 ± 2911 ± 612660 ± 956

  • ↵a Results are the mean ± error of two independent experiments.

  • ↵b Results are the mean ± S.D. of three independent experiments.