Statistical summary of diagnostic tests for the prediction of human subjective effects
Summary for prediction of human subjective effects, demonstrating the number of false positives, true positives, true negatives, false negatives, and outcome ratios for various statistical outputs with regard to diagnostic value. Values in parentheses indicate 95% confidence intervals. Values indicate a significant difference from pretest probability [concordance, PPV, NPV, PPV (30% prev), NHP (30% prev)] or from zero predictive value (VaPPV, VaNPV). PPV and NPV represent observed predictive values. PPV (30%) and NPV (30% prev) represent predictive values corrected for an estimated prevalence of 0.3.
| Model | False Positives | True Positives | True Negatives | False Negatives | Concordance | Sensitivity | Specificity | PPV | Adjusted PPV (30% prev) | Value Added PPV | NPV | Adjusted NPV (30% prev) | Value Added NPV | PRU Positive | PRU Negative |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Zebrafish CPP | 0 | 8 | 5 | 7 | 0.65 (0.43, 0.82) | 0.53 (0.30, 0.75) | 1.0 (0.57, 1.0) | 1.0 (0.68, 1.0) | 1.0 (0.29, 1.0) | 0.7 (-0.01, 0.70) | 0.42 (0.19, 0.68) | 0.83 (0.70, 0.92) | 0.13 (0, 0.22) | 1.0 (-0.01, 1.0) | 0.44 (0, 0.72) |
| Rat CPP | 2 | 13 | 3 | 1 | 0.84 (0.62, 0.94) | 0.93 (0.69, 0.99) | 0.6 (0.23, 0.88) | 0.87 (0.62, 0.96) | 0.5 (0.3, 0.87) | 0.2 (0, 0.57) | 0.75 (0.3, 0.95) | 0.95 (0.7, 1.0) | 0.25 (0, 0.3) | 0.28 (0, 0.82) | 0.84 (0.01, 0.99) |
| Rat self-administration | 2 | 13 | 2 | 1 | 0.83 (0.61, 0.94) | 0.93 (0.69, 0.99) | 0.5 (0.15, 0.85) | 0.87 (0.62, 0.96) | 0.44 (0.29, 0.84) | 0.14 (-0.01, 0.54) | 0.67 (0.21, 0.94) | 0.94 (0.62, 1.0) | 0.24 (-0.08, 0.3) | 0.20 (-0.02, 0.77) | 0.81 (-0.25, 0.99) |
NPV, negative predictive value, PRU positive, proportionate reduction in uncertainty for positive findings; PPV, positive predictive value; PRU negative, proportionate reduction in uncertainty for negative findings.