TABLE 1

Pharmacokinetic parameters of ponatinib in WT mice and hCYP1A1/2 pre-treated with TCDD or 3-MC

The PK parameters were calculated as outlined in Materials and Methods. The P values were calculated using an unpaired t test: *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.

Genotype	Pretreatment	t_1/2	C_max	AUC_{0–8 hours}	AUC_0–∞
		hour	µg/ml	hourµg/ml*	hourµg/ml*
WT	Vehicle	6.2 ± 0.2	1,212 ± 222	7,011 ± 1,490	12,620 ± 2,230
WT	TCDD	2.4 ± 0.8**	253 ± 42**	908 ± 59**	1,044 ± 175**
hCYP1A1/1A2	Vehicle	13.9 ± 1.7	705 ± 96	4,170 ± 500	9,740 ± 2,100
hCYP1A1/1A2	3-MC	4.6 ± 0.8**	620 ± 245	1,920 ± 520*	3,650 ± 1,890*