TABLE 2

Comparison of the epigenetic effects of different statins

SimvastatinAtorvastatinLovastatinPravastatinRosuvastatin
Histone acetylationDecreased HDAC expression (Karlic et al., 2015)Inhibited HDAC activity without altering expression. Increased H3 and H4 acetylation (Singh et al., 2016)Inhibited HDAC activity without altering expression. Increased H3 acetylation (Lin et al., 2008)Not reportedIncreased H3 and H4 acetylation. p300 recruitment (Feig et al., 2011)
Histone methylationDecreased EZH2 expression (Ishikawa et al., 2014)Not reportedNot reportedNo effect on EZH2 expression (Ishikawa et al., 2014)Not reported
DNA methylationDecreased DNMT expression (Karlic et al., 2015) Promoter demethylation (Kim et al., 2010)Not reportedInhibited DNMT activity without altering expression. Promoter demethylation (Kodach et al., 2011)Not reportedNot reported