Changes in cocaine choice A50: acute administration experiment
Values are given as group sizes (n) and group means (95% confidence limits). Doses are given in milligrams per kilogram per injection of cocaine that produced 50% cocaine choices.
| D2 | D3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Agonist (NPA) | Partial Agonist (Terguride ) | Antagonist (L-741,626) | Agonist (PD-128,907) | Partial Agonist (RGH-237) | Antagonist (PG01037) | ||||||||||||
| Dose | n | Group Mean | Dose | n | Group Mean | Dose | n | Group Mean | Dose | n | Group Mean | Dose | n | Group Mean | Dose | n | Group Mean |
| Vehicle | 7 | 0.18 (0.11–0.29) | Vehicle | 7 | 0.15 (0.11–0.21) | Vehicle | 8 | 0.21 (0.16–0.28) | Vehicle | 11 | 0.15 (0.11–0.19) | Vehicle | 8 | 0.21 (0.15–0.27) | Vehicle | 6 | 0.15 (0.11–0.21) |
| 0.01 | 5 | 0.16 (0.09–0.27) | 0.032 | 4 | 0.12 (0.06–0.26) | 0.32 | 8 | 0.21 (0.15–0.27) | 0.10 | 6 | 0.19 (0.17–0.20) | 10 | 8 | 0.11 (0.07–0.20) | 1.0 | 5 | 0.22 (0.15–0.34) |
| 0.032 | 6 | 0.06 (0.02– 0.18) | 0.10 | 7 | 0.15 (0.10–0.22) | 1.0 | 8 | 0.29 (0.17–0.48) | 0.32 | 7 | 0.29 (0.15–0.57) | 32 | 8 | 0.15 (0.07–0.30) | 3.2 | 8 | 0.14 (0.06–0.33) |
| 0.10 | 6 | 0.03 (0.02–0.08)* | 0.32 | 7 | 0.14 (0.10–0.20) | 3.2 | 9 | 0.44 (0.27–0.71)* | 1.0 | 8 | 0.21 (0.15–0.29) | 56 | 8 | 0.24 (0.17–0.33) | 10 | 8 | 0.14 (0.09–0.20) |
| 0.32 | 7 | 0.03 (0.01–0.06)** | 0.56 | 6 | Not calculated | 5.6 | 6 | Not calculated | 3.2 | 8 | 0.15 (0.05–0.44) | 18 | 6 | Not calculated | |||
| 0.56 | 6 | 0.03 (0.01–0.06)** | 1.0 | 6 | Not calculated | 5.6 | 6 | 0.05 (0.01–0.14)* | 32 | 8 | Not calculated | ||||||
| 1.0 | 4 | 0.04 (0.01–0.17) | |||||||||||||||
Not calculated indicates that responding was suppressed completely in more than one-half of the animals, resulting in missing percent choice values.
↵* P < 0.05; **P < 0.01 versus vehicle (Dunnett multiple-comparisons test after significant ANOVA).