Statistical analyses of effects of pretreatments on self-administration of DTG as shown in Fig. 5
Comparisons were made in the response rates of responses on the active lever maintained during each component compared with corresponding components after pretreatments with saline using a two-way repeated-measures ANOVA followed by post hoc Bonferroni t tests. The post hoc results are shown only if effects were statistically significant. The Δ values, in responses/second, were calculated as a subtraction of response rates maintained by cocaine after pretreatment with the BZT analog from those obtained after saline pretreatment.
| Pretreatment | Self-Administered DTG Unit Dose | Pretreatment Dose | Interaction | Post-Hoc Tests |
|---|---|---|---|---|
| AHN 1-055 | F4,60 = 6.30; P = 0.002 | F3,60 = 5.83; P = 0.008 | F12,60 = 5.85; P < 0.001 | 1.0mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 4.03, P < 0.001 (Δ = −0.304) |
| 3.2 mg/kg (i.p.) at 0.1 mg/kg/inj (i.v.), t = 5.13, P < 0.001 (Δ= +0.388) | ||||
| 3.2 mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 4.47, P < 0.001 (Δ= −0.338) | ||||
| AHN 2-005 | F4,60 = 9.41; P < 0.001 | F3,60 = 8.20; P = 0.002 | F12,60 = 6.13; P < 0.001 | 1.0mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 4.63, P < 0.001 (Δ= −0.180) |
| 3.2 mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 7.82, P < 0.001 (Δ= −0.303) | ||||
| JHW 007 | F4,60 = 10.2; P < 0.001 | F3,60 = 8.03; P = 0.002 | F12,60 = 7.48; P < 0.001 | 1.0mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 5.27, P < 0.001 (Δ= −0.196) |
| 3.2 mg/kg (i.p.) at 1.0 mg/kg/inj (i.v.), t = 8.12, P < 0.001 (Δ= −0.302) |
Inj, injection.