TABLE 1

Effects of anesthetics on TAS and LORR in WT and PRIP-1 KO mice

AnestheticDoseWTPRIP-1 KOEffect Sizec
naTASbnaTASb
mg/kg
Propofol400/60 (0–3)0/60 (0–21)0.40
603/71 (0–25)0/70 (0–3)1.03
804/636.5 (0–43)1/616.5 (0–24)d1.51
1006/752 (0–110)6/147.5 (0–45)d1.31
1207/797 (14–161)7/1321 (6–127)d0.92
1407/771 (54–149)10/1429 (6–79)d1.87
Etomidate50/60 (0–1)0/60 (0–3)0.07
82/102.5 (0–81)2/110 (0–41)0.67
107/821 (0–78)8/917 (0–86)0.21
206/647 (36–147)6/648 (19–101)0.05
309/9125 (82–180)10/10107.5 (58–180)0.72
Pentobarbital100/60 (0–0)0/63 (0–15)0.77
152/611.5 (0–29)2/512 (6–68)0.64
205/715 (5–22)5/715 (3–43)0.17
306/638.5 (24–46)9/930 (18–43)0.82
406/688 (41–136)6/671 (42–164)0.28
  • a Denominators represent the number of animals tested in each group. Numerators represent animals that showed LORR.

  • b TAS express the sum of anesthetic scores as median (range).

  • c Effect size (Cohen’s d) for TAS compared with WT mice with the same treatment.

  • d P < 0.05 versus WT mice with the same treatment (Mann-Whitney U test).