TABLE 2

Effects of OA on anesthetic-induced TAS and LORR in WT and PRIP-1 KO mice

AnestheticDoseOA DoseWTPRIP-1 KOEffect Size
naTASbnaTASb
mg/kg
Propofol14006/6121 (68–151)7/838.5 (3–99)c1.59d
1400.16/6169.5 (106–179)11/12148 (30–175)e0.87,d 1.33f
Etomidate3004/4112 (110–149)5/5110 (89–177)0.92d
300.14/4179 (99–181)5/5166 (16–180)0.70,d 0.79f
  • a Denominators represent the number of animals tested in each group. Numerators represent animals that showed LORR.

  • b TAS express the sum of anesthetic scores as median (range).

  • c P < 0.05 versus WT mice with the same treatments.

  • d Effect size (Cohen’s d) for TAS compared with WT mice with the same treatment.

  • e P < 0.05 versus PRIP-1 KO mice pretreated with OA (0 mg/kg) (Mann-Whitney U test).

  • f Cohen’s d for TAS compared with PRIP-1 KO mice pretreated with OA (0 mg/kg).