TABLE 1

Experimental groups design

Five experimental groups (n = 6) were formed as indicated. Control group received saline solution only. DEN was administered at 50 mg/kg i.p. once a week for 16 weeks and the IFC-305 compound at 50 mg/kg i.p. 3 times weekly during the DEN intoxication (HCC+IFC-305) or 6 weeks after DEN administration was stopped (CP+IFC-305).

GroupTreatment
16 weeks6 weeks
ControlSaline solution
HCCDEN + saline solution
HCC+IFC-305DEN + IFC-305
CPDENSaline solution
CP+IFC-305DENIFC-305
  • HCC, hepatocellular carcinoma; CP, cancer progression.