Concentrations of radioactivity in selected tissues after administration of [14C]naloxegol (50 mg/kg) to adult male and pregnant female rats
| Tissues | Concentration (μg Eq/g) | |||||
|---|---|---|---|---|---|---|
| (M/F) | 0.5 h | 1 h | 4 h | 24 h | 48 h | 168 h |
| Blood (M) | 3.03 | 4.11 | 2.14 | N.D. | N.D. | N.D. |
| Blood (F) | 12.38 | 7.80 | 6.92 | N.D. | N.D. | NST |
| Brain (M) | BLQ | 0.21 | 0.14 | N.D. | N.D. | N.D. |
| Brain (F) | 0.34 | 0.15 | 0.28 | ND.. | N.D. | NST |
| Large intestine wall (M) | 8.83 | 14.09 | 12.09 | N.D. | N.D. | N.D. |
| Large intestine wall (F) | 23.61 | 25.20 | 37.45 | N.D. | N.D. | NST |
| Liver (M) | 43.40 | 66.49 | 58.74 | 4.61 | 7.74 | 1.03 |
| Liver (F) | 68.67 | 56.01 | 58.78 | 4.42 | 2.68 | NST |
| Spinal cord (M) | 0.06 | 0.15 | 0.02 | N.D. | N.D. | N.D. |
| Spinal cord (F) | 0.24 | 0.10 | 0.12 | N.D. | N.D. | NST |
| Placenta (F) | 21.09 | 12.89 | 14.78 | 0.16 | BLQ | NST |
| Uterus (F) | 31.19 | 82.21 | 185.03 | 19.04 | 4.00 | NST |
| Fetus (whole) (F) | 3.10 | 1.99 | 2.23 | 0.17 | BLQ | NST |
BLQ, below the limit of reliable quantitation; N.D., not distinguishable; NST, no sample taken.