Urinary Biomarker | Vehicle | PF-249 | PF-06409577, 100 mg/kg | Ramipril | |||
---|---|---|---|---|---|---|---|
Lean | Obese | 3 mg/kg | 10 mg/kg | 30 mg/kg | |||
UACR (mg/mg) | 0.04 (0.03)**** | 20.32 (3.4) | 15.9 (4.8)* | 13.34 (3.06)*** | 5.34 (3.23)**** | 5.23 (4.54)**** | 9.00 (5.87)**** |
UPCR (mg/mg) | 2.39 (0.14)**** | 25.56 (1.53) | 20.32 (1.75)* | 17.29 (1.09)*** | 7.56 (1.06)**** | 7.47 (1.48)**** | 12.10 (1.93)**** |
TBAR/creatinine (nmol/mg) | 0.09 (0.01)**** | 0.17 (0.04) | 0.16 (0.03) | 0.14 (0.04) | 0.12 (0.03)** | 0.12 (0.04)** | 0.12 (0.05) ** |
TIMP1/creatinine (ng/mg) | 47.68 (15.84)**** | 127.79 (30.51) | 114.91 (22.17) | 103.5 (16.22) | 68.33 (16.52)**** | 65.70 (25.69)**** | 97.15 (40.76)* |
KIM-1/creatinine (pg/mg) | 3.30(0.12)**** | 12.36 (4.08) | 11.78 (3.63) | 10.74 (5.44) | 6.72 (2.51)** | 6.96 (3.83)** | 7.05 (1.85)** |
UACR, urinary albumin creatinine ratio; UPCR, urinary protein creatinine ratio; KIM-1, kidney injury marker-1.