Toxicology/Tissue | Biologic Tissue Response | Potential Imaging Probe |
---|---|---|
General markers | Inflammation | MMPSense 680 and 750 FASTa |
ProSense 680, 750EX, and 750 FAST | ||
Neutrophil Elastase 680 FAST | ||
Apoptosis/necrosis | Annexin-Vivo 750a | |
Vascular changes | AngioSense 680EX and 750EXa | |
Liver specific | Metabolism | Transferrin-Vivo 750a |
Kidney specific | Glomerular filtration | GFR-Vivo 680a |
Renin-angiotensin system | ReninSense 680 FAST | |
Stomach specific | Gastric emptying | GastroSense 680a |
Soft tissue calcification | Calcium deposition | OsteoSense 680 and 750a |
Cathepsin K activity | Cat K 680 FASTa |
↵a Probes that are commercially available with some validation data for use in preclinical drug-induced tissue injury applications (Peterson, 2016).