Mean plasma pharmacokinetics of LY3020371 following single oral doses of diester prodrug LY3027788.HCl in male Sprague-Dawley rats
| LY3027788.HCl dose (by Mouth) | LY3020371 Equivalent Dose (by Mouth) | Mean Rat Plasma Pharmacokinetic Parameter | |||
|---|---|---|---|---|---|
| Cmax | Tmax | AUC0–24 | T1/2 | ||
| mg/kg | mg/kg | nM | hour | nM/h | hour |
| 3 | 1.7 | 1540 | 0.5 | 4420 | 1.5 |
| 10 | 5.7 | 5590 | 0.8 | 14,700 | 2.9 |
| 30 | 17.2 | 9160 | 1.0 | 30,900 | 5.4 |