Effect of (R)-ketamine and (S)-ketamine on locomotor activity in mice and rats
| Mice | Rats | |
|---|---|---|
| Vehicle | 2217.5 (±139.7) | 1025.9 (±294.9) |
| (R)-Ketamine 10 mg/kg (i.p.) | 5029.5 (±782.1)* | 1869.9 (±289.5) |
| (R)-Ketamine 30 mg/kg (i.p.) | 16,654.5 (±1106.5)** | 4458.3 (±807.5)** |
| (S)-Ketamine 10 mg/kg (i.p.) | 6018.0 (±804.9)* | 1826.6 (±278.0) |
| (S)-Ketamine 30 mg/kg (i.p.) | 12,368.5 (±1106.5)** | 9547.1 (±1572.5)** |
↵* P < 0.05, **P < 0.01 versus vehicle (Dunnett’s test) (n = 8).