TABLE 2

Plasma, brain, and CSF concentrations of (R)-ketamine and (S)-ketamine following a single intraperitoneal administration to mice and rats

Data are presented as the mean ± S.D. of three animals. The LLOQ in plasma was 1 ng/ml (mice) or 0.1 ng/ml (rats); the LLOQ in brain was 0.5 ng/g for both species; the LLOQ in cerebrospinal fluid was 2 ng/ml (mice) or 0.2 ng/ml (rats).

DoseTime (hours)Concentration
PlasmaBrainCerebrospinal Fluid
hoursng/ml or ng/gng/ml or ng/gng/ml or ng/g
Mouse
 (R)-Ketamine
  10 mg/kg0.5210 ± 83.6513 ± 18157.3a
24<LLOQ<LLOQ<LLOQ
  30 mg/kg0.5958 ± 1552460 ± 384452a
24<LLOQ<LLOQ<LLOQ
 (S)-Ketamine
  10 mg/kg0.5376 ± 34.4527 ± 84.2127a
24<LLOQ<LLOQ<LLOQ
  30mg/kg0.51770 ± 2032310 ± 403330a
24<LLOQ0.823 ± 0.792<LLOQ
Rat
 (R)-Ketamine
  3 mg/kg0.557.9 ± 4.91118 ± 30.420.9 ± 5.27
24<LLOQ<LLOQ<LLOQ
  10 mg/kg0.5289 ± 38.1633 ± 10886.4 ± 13.9
24<LLOQ<LLOQ<LLOQ
 (S)-Ketamine
  3 mg/kg0.5105 ± 19.3235 ± 54.133.8 ± 7.47
24<LLOQ<LLOQ<LLOQ
  10 mg/kg0.5303 ± 73.6507 ± 76.390.1 ± 4.46
24<LLOQ<LLOQ<LLOQ
  • a Pooled sample of three mice.