TABLE 4

Bladder capacity increases with combined treatments with vibegron and tolterodine and darifenacin in rhesus monkeys

Values in table represent Mean ± SEM of % increase over baseline (N=4).

VehicleVibegron
0.0030.010.030.10.31
mg/kg
Vehicle4.1 ± 3.518.0 ± 5.727.3 ± 5.133.9 ± 9.531.3 ± 5.055.9 ± 18.5
Tolterodine0.0110.7 ± 5.0a26.7 ± 4.931.0 ± 6.3
0.0316.8 ± 13.9a35.5 ± 9.336.4 ± 4.043.4 ± 6.8
0.140.3 ± 9.8a62.9 ± 8.356.8 ± 8.169.6 ± 14.6
Darifenacin0.018.9 ± 7.1a13.7 ± 4.023.7 ± 3.3
0.0318.3 ± 8.6a37.1 ± 9.443.3 ± 12.6
0.129.4 ± 8.9a58.0 ± 19.568.7 ± 20.9
  • a Data from previous publication (Nagabukuro et al., 2011)