Phase 1, percent changes in respiratory parameters after 4-weeks in Pompe mouse given vehicle or Reveglucosidase alfa
| Respiratory Parameter | Treatment Groups | ||
|---|---|---|---|
| WT (N = 5) | Pompe Vehicle (N = 5) | Pompe 20 mg/kg Reveglucosidase Alfa (N = 5) | |
| % Change Relative to Baseline | % Change Relative to WT | ||
| TVa | ↑365% | ↓10% | ↑13% |
| MVa | ↑394% | ↓27% | ↓5% |
| PIF | ↑260% | ↓26% | ↓7% |
| RR | ↓24% | ↓13% | ↓16% |
| Ti | ↑31% | ↓19% | ↓22% |
TV = MV*RR; RR, respiratory rate.
↵a There were no notable differences in body weight among the animals over the course of the study; therefore, these parameters were not normalized for body weight.