TABLE 1

hFRGN human donor and human liver tissue information

All hFRGN livers were >80% human repopulated, as indicated by Yecuris. Human liver tissues were from In Vitro ADMET, Columbia, MD

Mouse IDHuman Donors IDDonor InformationHuman AlbuminExperiments
mg/ml
hFRGN3HHF07007Female, Caucasian, 7 years old7.2Liver mRNA and protein
hFRGN4HHF07007Female, Caucasian, 7 years old4.9Liver mRNA and protein
hFRGN5HHF07007Female, Caucasian, 7 years old4.6Liver mRNA and protein
hFRGN6HHF07007Female, Caucasian, 7 years old5.3mRNA and protein; bile acid LC-MS/MS
hFRGN7HHF07007Female, Caucasian, 7 years old15.5mRNA and protein; bile acid LC-MS/MS
hFRGN10HHM05010Male, Caucasian, 5 years old4.8Liver mRNA and protein
hFRGN11HHM05010Male, Caucasian, 5 years old4.0mRNA and protein; bile acid LC-MS/MS
hFRGN12HHM05010Male, Caucasian, 5 years old4.0Histology
hFRGN13HHF17006Female, Caucasian, 17 years old6.3mRNA and protein; bile acid LC-MS/MS
hFRGN14HHF17006Female, Caucasian, 17 years old7.1mRNA and protein; bile acid LC-MS/MS
hFRGN15HHF17007Female, Caucasian, 7 years old5.7mRNA and protein; bile acid LC-MS/MS
hFRGN16HHF17007Female, Caucasian, 7 years old4.4mRNA and protein; bile acid LC-MS/MS
hFRGN26HHF17006Female, Caucasian, 17 years old5.2Bile acid pool size LC-MS/MS
hFRGN27HHF17006Female, Caucasian, 17 years old3.9Bile acid pool size LC-MS/MS
hFRGN28HHF17006Female, Caucasian, 17 years old3.5Bile acid pool size LC-MS/MS
hFRGN29HHF17006Female, Caucasian, 17 years old3.5Bile acid pool size LC-MS/MS
Human liver 1H1016Female, Hispanic, 64 years oldNALiver mRNA
Human liver 2H1028Male, Hispanic, 43 years oldNALiver mRNA
Human liver 3H1041Male, Caucasian, 53 Years oldNALiver mRNA
Human liver 4H1047Male, Hispanic, 44 years oldNALiver mRNA
Human liver 5H1057Female, Caucasian, 33 years oldNALiver mRNA
Human liver 6H1072Female, Caucasian, 40 years oldNALiver mRNA
  • NA, not available.