TABLE 2 

Linear regression analysis of CYP2A6 protein levels (pmol/mg)a

Predictor VariableBBeta95% CI% Variation Accounted fordP Value
1 Model 1bCYP2A6*2 genotypee−11.8−0.2−20.0 to –3.72.7%<0.01
CYP2A6*9 genotypee−6.1−0.1−12.2 to –0.081.3%<0.05
CYP2A6*12 genotypee−11.4−0.1−23.2 to 0.51.2%<0.1
Gender (M = 1, F = 0)−2.2−0.06−6.8 to 2.30.3%>0.1
AKR1D1 mRNA (FPKM)0.20.30.1 to 0.39.1%<0.001
Age0.10.10.01 to 0.21.6%<0.05
2 Model 1 + CYP2A6 mRNAcCYP2A6*2 genotypee−13.6−0.2−20.8 to –6.43.5%<0.001
CYP2A6*9 genotypee−3.8−0.07−9.1 to –1.50.5%>0.1
CYP2A6*12 genotypee−8.0−0.08−18.4 to 2.30.6%>0.1
Gender (M = 1, F = 0)−2.1−0.05−6.1 to 1.90.3%>0.1
AKR1D1 mRNA (FPKM)0.070.10.001 to 0.11.0%<0.05
Age0.10.10.01 to 0.21.2%<0.05
CYP2A6 mRNA (FPKM)0.020.50.02 to 0.0220.0%<0.001
  • a Cases excluded pairwise.

  • b R2 = 0.17, P < 0.001.

  • c R2 = 0.37, P < 0.001.

  • d % Variation accounted for by each variable is determined by: (Part Correlation)2 × 100.

  • e CYP2A6*2, CYP2A6*9, and CYP2A6*12 genotypes coded as 0 for CYP2A6*1/*1 genotype, 1 for CYP2A6*1/*2, CYP2A6*1/*9, or CYP2A6*1/*12 genotypes, and 2 for CYP2A6*2/*2 or CYP2A6*9/*9 genotypes.