TABLE 3

Serum liver enzymes and total liver triglycerides from CDAHFD study

All values represent the mean ± S.E.M.

TreatmentALTASTALPTotal BRLiver Tg
U/lmg/dlnmol/mg
Normal chow/Vehicle25 ± 1141 ± 1654 ± 30.17 ± 0.0219 ± 1
CDAHFD/Vehicle260 ± 19290 ± 14106 ± 30.41 ± 0.04200 ± 3
CDAHFD/PAT-505217 ± 19225 ± 13a106 ± 40.20 ± 0.02b182 ± 3b
  • ALP, alkaline phosphatase; ALT, alanine transaminase; BR, bilirubin; Tg, triglycerides.

  • a P = 0.01;

  • b P < 0.001 vs. CDAHFD/Vehicle.