TABLE 2

Pharmacokineic parameters for PAT-505 in mouse and rat after either intravenous (i.v.) or oral (PO) administration

ParameterMouseRat
i.v.POi.v.PO
Dose (mg/kg)5300.210
AUC (h*µg/ml)42.4145.613.0337.7
Dose-adjusted AUC8.54.96533.8
ClPl (ml/min/kg)2.00.22
VDss (l/kg)0.410.16
t1/2 (h)3.93.310.26.9
%F5752
C0 (µg/ml)59.14.1
Cmax (µg/ml)22.733.9
Tmax (h)4.03.3
  • AUC, area under the curve; C0, initial concentration t; Cmax, maximum concentration; ClPl, plasma clearance; t1/2, half-life; %F, oral bioavailability; Tmax, time of maximum concentration; VDss, volume of distribution at steady state.