TABLE 4

Slopes of CaCl2-induced contractions

The CaCl2-induced contraction slope values for intracellular calcium predepleted tracheal preparations in histamine (3 × 10−6 M) or methacholine (5 × 10−7 M) containing Ca2+-free KH solution.a b

CaCl2 Added to Histamine Containing Ca2+-Free Medium (×10−3)P <CaCl2 Added to Methacholine Containing Ca2+-Free Medium (×10−3)P <
Control9.7 ± 3.219.6 ± 5.9
10−5M Drotaverine1.2 ± 1.10.0013.5 ± 2.50.01
Control19.1 ± 1311.8 ± 4.6
10−5M Papaverine1.1 ± 0.50.050.8 ± 0.30.01
control11.4 ± 4.210.1 ± 3.3
10−5M Nifedipine1.1 ± 0.40.0011.0 ± 0.50.01
control14.5 ± 5.013.7 ± 2.4
10−5M Diltiazem2.4 ± 1.10.0010.7 ± 0.30.001
Control10.6 ± 3.612.6 ± 6.4
10−5M Theophylline13.9 ± 4.1n.s.8.4 ± 1.4n.s.
Control13.9 ± 3.317.9 ± 9.4
10−5M Theophylline +10−5M Nifedipine0.9 ± 0.30.0010.9 ± 0.20.05
  • a The slope values represent the mean ± SD (n = 4–8).

  • b Student’s t test was used to compare the nontreated to the treated slope values.