Drug | Emax (% DAR) | ED50 (mg/kg) | Slope | |||
---|---|---|---|---|---|---|
Mean | (S.E.M.) | Mean | (95% CI) | Mean | (S.E.M.) | |
Cocainea | 100 | (0.0) | 4.9 | (4.2–5.9) | 1.7 | (0.08) |
Saline | 1.8 | (1.5)* | n.a. | n.a. | n.a. | n.a. |
Caffeinea | 77.5 | (6.3)* | 14.4 | (9.5–21.9) | 1.2 | (0.12) |
MDPV | 98.3 | (1.1) | 0.39 | (0.25–0.58) | 2.1 | (0.33) |
Methamphetamine | 99.8 | (0.2) | 0.37 | (0.34–0.41) | 2.3 | (0.32) |
Midazolam | 7.6 | (5.0)* | n.a. | n.a. | n.a. | n.a. |
n.a., not applicable.
↵a Emax, ED50, and slope parameters were derived from two sets of dose-response curves determined in triplicate (i.e., six dose-response curves).
↵* Significant difference from cocaine as determined by one-way analysis of variance with repeated measures and post-hoc Dunnett’s test for multiple comparisons.